England vs Ireland live: Latest score and updates as Six Nations rivals meet in must-win clash to keep title hopes alive

And here’s why England have turned to a sort of human Berocca to help cure their Edinburgh hangover:

Another real character within the English squad is Henry Pollock, hard to miss with his bleached blond hair. Steve Borthwick sent a message of advice to the No 8 as he prepares for his first international start:

Joe Heyes has had to source more than 20 tickets at Twickenham today, largely for the friends and extended family of his Irish mother. He’s a fascinating, and charming, character, as I found out in November:

England’s scrum, meanwhile, has been going rather well. One of those looking to do the dismantling today will be Joe Heyes, among their most improved performers in the last 12 months – even if not everyone knows who he is just yet…

Another major concern for Ireland from the Italy win was the performance of their scrum. What has gone wrong with their set-piece, and how might England exploit it?

Ireland boss Andy Farrell backed Sam Prendergast to bounce back from being dropped as he admitted neither of his leading fly-halves were in particularly good form ahead of the Six Nations.

Prendergast has been left out of the matchday squad for today’s round-three clash away to England following a tough outing in last weekend’s tense 20-13 win over Italy.

Jack Crowley will start at Twickenham after his impressive cameo against the Azzurri, with Ciaran Frawley providing back-up from the bench.

Prendergast, 23, began six of Ireland’s last seven Six Nations fixtures and has been overlooked for a matchday 23 in the championship for the first time.

There was little surprise when Jack Crowley was named at No 10 on Thursday. As Luke Baker explained earlier this week, the time had come to take Sam Prendergast out of the firing line:

For Ireland, meanwhile, there is a change at fly half with Jack Crowley in and Sam Prendergast out of the 23 altogether.

For England, it’s a day of milestones – a first start for Henry Pollock, a century of caps for Maro Itoje:

It’s win or bust for England and Ireland as two Six Nations title hopefuls meet at Twickenham’s Allianz Stadium. Defeats to Scotland and France respectively mean that neither nation can afford another set-back if they are to challenge for the championship, leaving plenty on the line as round three kicks off.

The action gets underway at 2.10pm GMT.