How old is YOUR liver? Take our 6-step test to find out if you’re at risk of fibrosis and cirrhosis… and the easy lifestyle tweaks to de-age the organ FAST

Your liver could be years older than you think, and you may not feel a thing. 

More than 110 million Americans have liver disease, estimates suggest – that’s a four-fold surge from the 1980s. But most people have no idea they’re affected.

Now, with the help of physicians, the Daily Mail has created a tool that can help estimate your liver’s age – and advise whether it’s time to see a doctor.

‘The liver has this incredible capacity to compensate more so than most organs,’ Dr Quin Wills, a physician who has spent two decades studying the organ, told the Daily Mail.

‘That being said, however, very often, you will be fine… until, suddenly, you are not [because symptoms come on rapidly].’

An increase in obesity and type 2 diabetes rates have driven the uptick in liver problems because the diseases can scar the organ and impair its function. Alcohol consumption can also drive up liver age.

The organ is among the most important in the body. It is responsible for more than 100 functions, from filtering blood to storing fats and regulating hormones. It is also the only organ that is able to regrow, regenerating about half of itself within 30 days, according to doctors. 

Still, it is not invincible. This test will help you determine where your liver stands according to your lifestyle, habits and health.

Understanding your results 

The test reveals your liver’s estimated age on a scale of zero to seven years.

Our posed questions reflect factors that doctors and other experts have said could severely impact the health of the organ.

Dr Wills warned that a result above three years suggests there may be strain on your liver, which could lead to complications. He recommends seeking a doctor’s opinion if you are concerned.

Read on to understand the risks, side effects and symptoms associated with unhealthy livers.

All healthy livers are about three years old

In a 2022 study, researchers analyzed liver tissue from 32 patients between the ages of 20 and 84.

Results showed that liver cells lived for about a year on average, and the vast majority never lived longer than three years. Researchers found that once the cells hit these ages, they generated new copies of themselves before dying off.

‘No matter if you are 20 or 84, your liver stays on average just under three years old,’ Dr Olaf Bergmann, who led the study, said.

Alcohol has wide-ranging effects on liver age

US health agencies warn that heavy drinking – more than 15 drinks per week for men or eight for women – can severely damage the liver.

Previous research warned that drinking this much over two decades significantly raised the risk of liver cirrhosis, where healthy liver tissue is permanently replaced by scar tissue. A separate study from 2018 found those with alcohol-induced cirrhosis had been drinking for 22 years on average.

Liver cirrhosis is a chronic, late-stage complication. Beforehand, a patient suffers from alcoholic fatty liver disease (excess fats build up in the organ), liver inflammation (the fats inflame the organ) and fibrosis (scarring and stiffening of the liver caused by inflammation).

Patients diagnosed with liver cirrhosis have an average life expectancy of seven years, according to the Cleveland Clinic.

Alcohol can cause this complication because it is broken down into toxic chemical acetaldehyde in the liver before being turned into a neutral chemical. Alcoholic drinks also tend to be high in calories, which can cause fats to accumulate in the organ over time.

‘We do know that obesity and alcohol do contribute to the inflammation of the liver… and we know that the long-term impact of that is fibrosis,’ Wills, who co-founded liver research company Ochre Bio, told the Daily Mail.

‘But, from my research, I found that the variability of the impact alcohol has on the liver is enormous. We are still not quite sure why that is.’

He said some people can drink a lot and suffer relatively little damage, while others can drink little and suffer a fair amount of damage. It is not clear why, but previous research has suggested it may be linked to genetics or pre-existing health conditions.

Waist size as a predictor of a sick liver

The most common liver disease in the US is linked to food consumption.

Non-alcoholic fatty liver disease is caused by a build-up of fats in the liver that cause inflammation and impact function. Doctors say the build-up can be triggered by type 2 diabetes, poor diet, or by the patient being overweight or obese.

About 100 million Americans are estimated to suffer from the disease, which doctors say can only be diagnosed via blood tests or scans. But studies suggest it could also be diagnosed by measuring the size of your waist. 

In the 2024 guidelines from the European Association for the Study of the Liver, physicians noted a waist size above 37in (94cm) in men and 31.5in (80cm) in women may indicate that a person has the disease.

In a separate 2022 study from Korea, scientists found men with a waist size above 31.8in (81cm) and women with a size above 30.9in (78.5cm) were more than twice as likely to be diagnosed than those below this measure.

It rarely causes symptoms, with a 2021 study warning that 96 percent of affected Americans are unaware. In cases where symptoms do appear, patients may feel tired or have discomfort on the upper right side of their abdomen.

Waist size is a strong measure because it accounts for visceral fat that surrounds abdominal organs. However, Wills warned that in about one out of six cases, the disease affects people who are lean – meaning it would not be detected by measuring waist size.

The disease can cause fibrosis and cirrhosis over the course of a decade or more.

According to the Mayo Clinic, those with fatty liver disease live, on average, three years less than those who do not have the condition.

How type 2 diabetes ages the liver

Type 2 diabetes, which affects 38 million people in the US, also ages the liver, according to doctors.

A 2023 study that tracked 30,000 type 2 diabetes patients for 20 years found those who had the condition for five years or less were 150 percent more likely to suffer from liver complications.

For comparison, those who had the disease for 10 years or more were found to be 520 percent more likely to develop problems with the organ.

The complications included were liver cancer, failure and cirrhosis.

Type 2 diabetes ages the liver by causing excessive fat storage, which raises the risk of premature cell death and fibrosis.

This can also raise the risk of cancer by prompting damaging mutations to build-up in cells.

While it is considered uncommon for diabetics to need a liver transplant, a quarter of the 10,000 patients who received a transplant in 2023 had the disease.

Wills warned that while type 2 diabetes does age the liver, if it is well-controlled, it would likely not cause rapid aging.

Infections that age the liver 

Hepatitis B and C are two viruses that attack the liver, trigger inflammation and cause major scarring to the organ. 

Both are contracted when someone comes into contact with infected blood or bodily fluids. There is no cure for hepatitis B, which affects 1.5 million Americans. But patients are able to live long and healthy lives, Wills said, so long as they take proper antiviral medications.

For hepatitis C, however, which affects 2.4 million Americans, doctors may be able to clear the infection using antiviral treatments.

Wills warned that both conditions raise the risk of liver disease, scarring and cancer.

Most patients do not need a liver transplant because antiviral drugs slash damage to the organ and reduce the risk of it failing. 

How can I reverse my liver age?  

Although damage can accumulate, researchers say it may be possible to bring the organ back to good health.

‘Behavioral change is still the best form for looking after the liver,’ Wills told the Daily Mail.

‘For obese people, it is to lose weight, either through diet or, if you can’t, weight loss jabs, which are fantastic options. Exercise also absolutely will boost liver health.’

The World Health Organization urges all adults to get 150 to 300 minutes of moderate-intensity exercise, such as brisk walking or cycling, every week, and train muscles twice a week.

Limiting alcohol consumption can also boost liver – and overall – health, Wills said. Previous guidelines suggested no more than two drinks a day for men and one drink a day for women.

Wills added that drinking coffee could boost liver health, referring to studies that found consuming two cups a day may help.

In a 2017 study on 1,000 patients with fatty liver disease, researchers found that those who drank two coffees a day had lower liver stiffness than those who did not.

When should I go to the doctor?

‘If you have a large weight and one other factor… of high blood pressure, high blood sugar or high blood cholesterol, then you should consider going to the doctor [to check on your liver],’ Wills said.

‘That is a big, big, big red flag that you might have fatty liver disease.’

Patients should also see a doctor if they are suffering from jaundice, a yellowing of the whites of the eyes, or a dull pain in their abdomen.