A popular supplement has been linked to the deaths of six people in California. But no one knows the exact danger it poses
California officials have banned the sales of kratom, a popular supplement often used to treat pain and anxiety, after finding it was linked to six deaths in Los Angeles County, but what role the supplement played remains a mystery.
Kratom is a tropical tree native to Southeast Asia; 7-OH is a natural psychoactive component found in kratom leaves in trace amounts. But there’s a growing popularity of concentrated versions — offered as tablets, gummies, and liquid extracts — which are synthetic, according to the FDA.
Neither kratom nor 7-OH are regulated or approved for use in the U.S. as a drug product, a dietary supplement, or a food additive, according to the FDA. In July, the agency issued warning letters to companies that were “illegally marketing products” containing 7-OH.
Since the spring, six people between the ages of 18 and 40 have died after ingesting products containing 7-OH, Los Angeles County Department of Public Health said. The department this month advised retailers to stop selling products that contain kratom and the synthetic kratom compound 7-OH from their shelves.
These products are often marketed as dietary supplements, used to alleviate pain, anxiety and mood disorders, opioid withdrawal, LA County health officials said.
“At lower doses, 7-OH acts like a stimulant and at higher doses, it acts like an opioid. Mixing or using it with alcohol, prescription drugs, or illicit substances can significantly slow breathing and lead to death,” Dr. Muntu Davis, Los Angeles County Health Officer, said in a statement. “The safest choice is to avoid all 7-OH products.”
The county isn’t alone. Some local governments have adopted bans on kratom products and at least six states — Alabama, Arkansas, Indiana, Rhode Island, Vermont and Wisconsin — have banned 7-OH, according to a 2023 report by the Congressional Research Service.
The FDA warned consumers to avoid using kratom “because of the risk of serious adverse events,” such as seizures, noting it has been linked to deaths “in rare cases.” But, the agency noted that in these cases, “kratom was usually used in combination with other drugs, and the contribution of kratom in the deaths is unclear.”
That was true in the deaths reported in LA County this year tied to kratom use. Health officials noted that alcohol, medications or illicit substances were also found alongside 7-OH. Medical examiners’ reports, obtained by the Los Angeles Times, showed the cause of five of the deaths was listed as a consequence of “mixed drug effects.” The sixth death was caused by a cocaine overdose.
Toxicologists told the LA Times that there was insufficient research to show what concentrations of kratom can be toxic when not mixed with another substance.
“I don’t claim to have investigated all the reports about kratom deaths, but I haven’t seen too many reports of single-drug ingestions of kratom causing death,” Craig Smollin, medical director of the San Francisco division of the California Poison Control System, told the paper.
On top of lack of research, the testing methods may not be effective, experts say. There is a test to show how much kratom is in the body, but no such test exists for 7-OH. The existing test merely shows whether 7-OH was present or not, according to the LA Times.
Perhaps further complicating measures, when the body metabolizes kratom, part of the breakdown includes 7-OH, making the compound likely to appear in medical tests alongside kratom, Donna Papsun, a forensic toxicologist at NMS Labs in Pennsylvania, told the outlet.
Testing results may also be complicated because 7-OH is also “incredibly unstable,” Papsun said, noting that while it may be detected at the time of death, in the time that passes until samples are collected, it may have already broken down.
